Research

Research

Research
Research
Use of the LEAP Mediator Release Test to Identify Non-IgE Mediated Immunologic Food Reactions that Trigger Diarrhea Predominant IBS Symptoms Results in Marked Improvement of Symptoms Through Use of an Elimination Diet
American College of Gastroenterology, Annual Scientific & Educational Meeting, Orlando, Florida, November 2004, Fred H. Williams, MD, Department of Gastroenterology, St. John’s Mercy Medical Center, St. Louis, Missouri, United States

BACKGROUND

Diarrhoea predominant IBS (D-IBS) is a common condition that is often refractory to standard therapy. Though some treatments may improve certain symptoms, there is no treatment that has been shown to result in the improvement of global D-IBS symptoms. The Lifestyle Eating and Performance Mediator Release Test (LEAP MRT) is an in vitro test that detects non-IgE mediated food reactions that can trigger D-IBS symptoms. We report on our early experience with this dietary modification program.

METHODS

Ten patients who met Rome II criteria for D-IBS are reported in this study. These patients presented to our community-based gastroenterology practice and were evaluated by a gastroenterologist. Evaluation for other causes of their symptoms was based on the patient’s previous evaluation and the discretion of the gastroenterologist. Typically, if not already employed in the past, a trial of standard therapy such as fibre and anti-spasmodic agents was attempted. If the patient didn’t improve, they were then offered LEAP MRT testing. Using an in vitro assay, the patient’s blood was tested for non-IgE mediated reactivity to150 foods and food additives. A specific elimination diet that omitted the reactive foods was then designed for the patient. A Symptom Survey was employed to follow the patients for improvement in D-IBS as well as systemic symptoms. The survey graded multiple GI and systemic symptoms on a scale of 0-4 with increasing severity represented by a higher number. The maximum points possible for the entire survey was 236 and for the GI portion was 36.

RESULTS

Prior to beginning the LEAP MRT based elimination diet, the average score for the entire survey was 56.9 and for the GI portion was 19.1. After at least one month on the diet, the average scores had decreased to 26.3 and 6.3 respectively. Patients generally reported a marked improvement in their D-IBS symptoms, decreased systemic symptoms, and an overall increase in their feeling of well-being.

CONCLUSION

The LEAP MRT identifies non-IgE mediated immunologic food reactions that trigger D-IBS symptoms. Elimination of these foods from the diet results in a marked improvement in D-IBS and other systemic symptoms.

Peer-Reviewed Manuscripts
  1. Pasula MJ, Nowak J. Particle size measurement in suspensions: Part 1–A laboratory. method for exploring food allergies and sensitivities in illness. Am Clin Lab. 1999;18(4):16-18. https://pubmed.ncbi.nlm.nih.gov/10539096/
  2. Pasula MJ. Particle size measurement in suspensions. Part 2: An in vitro procedure for screening adverse reactions to foods and chemicals. Am Clin Lab. 1999;18(9):14-15. https://pubmed.ncbi.nlm.nih.gov/10623324/
  3. Kaczmarski M, Pasula M, Sawicka E, Werpachowska I. MRT test – New generation of tests for food hypersensitivity in children and adults. PrzegladPediatryczny.1997(SUPLEMENT 1):61-65. http://dietetykametaboliczna.com/publikacje/
Published Abstracts
  1. Patenaude J & Bright D. Clinical improvement of IBS, migraine, fibromyalgia and arthritis using elimination diets based on mediator release blood testing. Journal of the American Dietetic Association, Volume 109, Issue 9, Supplement, 2009, Page A32, ISSN 0002-8223, https://doi.org/10.1016/j.jada.2009.06.092. (http://www.sciencedirect.com/science/article/pii/S0002822309008645).
  2. Williams F. Use of the LEAP mediator release test to identify non-IgE mediated immunologic food reactions that trigger diarrhea predominant IBS symptoms results in marked improvement of symptoms through use of an elimination diet. American Journal of Gastroenterology: October 2004 – Volume 99 – Issue – P S277-S278. (https://journals.lww.com/ajg/Fulltext/2004/10001/USE_OF_THE_LEAP_MEDIATOR_RELEASE_TEST_TO_IDENTIFY.847.aspx).
Magazine Publications
  1. Patenaude J. Behavioral Nutrition Health Roundtable.Obesity in the age of weight neutrality: How are registered dietitian nutritionists responding to the challenge?Academy of Nutrition and Dietetics. BHNewsletter, Spring 2020, Volume 37 No. 1, Page 5.https://www.bhndpg.org/wp-content/uploads/2020/07/BHNews-Spring2020_FINAL-2.pdf
  2. Patenaude J. Inflammation and food sensitivities — successful treatment begins with patient-centered care. Today’s Dietitian, November 2011 Issue; Vol. 13 No. 11 P. 18. https://www.todaysdietitian.com/newarchives/110211p18.shtml
  3. Alternative approach to IBS and migraine is winning over providers. Dis ManagAdvis. 2004;10(1):6-1.https://pubmed.ncbi.nlm.nih.gov/15007999/
Poster Presentations/Conferences
  1. Bethel LJ. Self-assessment of frequency and severity of symptoms with chronic inflammatory conditions following a patient-specific elimination diet and food reintroduction plan. Florida Dietetic Association Annual Meeting. Orlando, FL. July 2010.
Publications in Progress/ Preparation
  1. Zarini GG, Masters J, McLean MA, Strobel CT. Clinical and anthropometric improvements with a tailored dietary approach for pediatric Crohn’s disease. Pediatric Health, Medicine and Therapeutics, 2020. Under review.
  2. Linke S, Patenaude J, Zarini GG, McLean MA. Tailored Dietary Approach to Manage Irritable Bowel Syndrome. Lifestyle Medicine Conference,October 2020. Under review.
  3. Braunstein N, Hogan M, Diaz R. The Lifestyle Eating and Performance (LEAP) program for improving quality of life in women with PCOS: A pilot study of dietitian-directed therapy. In preparation.
  4. Zarini GG, McLean MA. Tailored oligoantigenic based dietary approach for migraine. In preparation.